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Senior Research Associate I/II

Company: Ultragenyx Pharmaceutical Inc.
Location: Novato
Posted on: June 20, 2022

Job Description:

Why Join Us?
Be a hero for our rare disease patientsAt Ultragenyx, we fundamentally believe that taking real impactful action to care for the needs of patients and our people is always the right thing to do. To achieve this goal, our vision is to lead the future of rare disease medicine. For us, this means going where other biopharma companies won't go - challenging the status quo and creating a new model that advances our field so more patients and caregivers can benefit from life-changing treatments. We do this by following the science, applying a novel rapid development approach, making innovative medicines at fair and reasonable prices, and creating a collaborative ecosystem to reach patients in ways that are most meaningful for them.Our commitment and care for patients extends to our people, so culture is an essential cornerstone for Ultragenyx. We remain continuously focused on creating a supportive and inclusive environment of profound learning and growth - so employees can thrive in all areas of their lives, in and outside of work. Ultimately, we want to be an organization where we would be proud for our family, friends and children to work.If you want to have a meaningful impact, do the best work of your career, and grow a lot, both professionally and personally, come join our team. During the COVID-19 pandemic, we are committed to the health and safety of our employees and prospective employees, which means at this time our interview processes may include virtual discussions, interviews, and onboarding. Please note that compliance with local regulations and safety protocols is a condition of employment at Ultragenyx. Elements of safety protocols may include, but are not limited to: work from home requirements, regular or symptom-based covid testing, providing valid evidence of vaccination, mask wearing, and physical distancing.US based roles: Full vaccination against COVID-19 is a condition of employment at Ultragenyx. This requirement applies to almost all roles at Ultragenyx based in the U.S., with very limited exceptions. If you are unable to receive a COVID-19 vaccine due to a disability, serious medical condition, or because it would violate your sincerely held religious belief, you will have an opportunity to request a reasonable accommodation.Roles based outside the US: If the role requires travel to the US or another country that requires evidence of covid vaccination for entry, candidates and employees will be required follow the local regulations and corporate policy regarding vaccination evidence submission.
Position Summary:The Senior Research Associate will be part of the Research department and will provide expertise in the development, optimization, and execution of analytical characterization for a broad range of biomolecules. These efforts will support preclinical research programs in the area of rare disease therapeutics.

The Senior Research Associate will be responsible for deployment, maintenance, and expert use of complex analytical tools such as HPLC, mass spectrometry, and fluorimetry to characterize nucleic acids, lipids, carbohydates, proteins and peptides. Responsibilities include planning and execution of experimental work, data analysis and presentation of material at project team meetings.The candidate is expected to collaborate and work dynamically on diverse projects/platforms, communicate effectively on scientific concepts, and interact with colleagues in other functional areas. Cross-functional collaboration with Technical Operations and Contract Research Organizations may be required for technology transfer of analytical methods that support development efforts.Work Model:Core Lab & Ops: majority of the work requires being in the office or laboratory either pre, during or post pandemicResponsibilities:

  • Understand Ultragenyx therapeutic project objectives and work within research teams to develop effective experimental plans and effectively execute associated bench work.
  • Collaborate with internal team members, external collaborators, and CROs to execute experiments and provide technical insight into appropriate use of scientific instrumentation.
  • Perform rigorous quantitative and qualitative analysis of a wide range of biological molecules including nucleic acids using key analytical methodologies such as column chromatography, HPLC, LC-MS, LC-MS/MS, gel electrophoresis, and UV-Vis spectrophotometry.
  • Maintain and troubleshoot complex analytical instrumentation such as high pressure and standard pressure chromatography systems, mass spectrometers and their associated data platforms.
  • Critically analyze experimental results and communicate results on a timely basis.
  • Maintain detailed records of experimental protocols and laboratory procedures.
  • Generate and distribute thorough data analysis reports.
  • Present research findings to lab group and project teams.
  • Provide insights for continuous improvement in productivity and capabilities.
  • Prepare technical reports for regulatory documents including Investigational New Documents (IND) or Clinical Trial Applications (CTA)
  • Contribute to patent application fillings and manuscript preparations for submission.Requirements:
    • Title / Level commiserate with education and experience
    • SRA I: Degree in Chemistry, Pharmaceutical Sciences, Biochemistry, Chemical Engineering, bioengineering or other industry-relevant fields. MS with 2+ years of related experience, or BS/BA with 4+ years of related experience
    • SRA II: Degree in Chemistry, Pharmaceutical Sciences, Biochemistry, Chemical Engineering, Bioengineering or other industry-relevant fields. MS with 4+ years of related experience, or BS/BA with 6+ years of related experience
    • Post-graduation hands-on laboratory experience deploying analytical tools for the quantitative and qualitative analysis of lipids, nucleic acids, proteins and small molecules
    • Experience in bio/analytical and biophysical methods used for characterization of LNP formulations and knowledge of the technologies required for formulation optimization
    • Direct experience with the troubleshooting and maintenance of high complexity analytical instrumentation
    • Knowledge of the nucleic acid manufacturing process is desired
    • Knowledge of mass spectrometry techniques for bioanalysis of nucleic acids is desired
    • Excellent data recording and ensuring high quality, timely documentation in laboratory notebook
    • This position requires excellent organizational skills, agility and time management in order to meet deadlines in a fast-paced organization
    • Demonstrated independence at the bench and ability to work collaboratively on projects
    • Effective communication and presentation skills#LI-AH1
      Full Time employees across the globe enjoy a range of benefits, including, but not limited to:

      • Generous vacation time and public holidays observed by the company
      • Volunteer days
      • Long term incentive and Employee stock purchase plans or equivalent offerings
      • Employee wellbeing benefits
      • Fitness reimbursement
      • Tuition sponsoring
      • Professional development plans
        • Benefits vary by region and country
          Ultragenyx Pharmaceutical is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital and veteran status. Reasonable accommodation will be provided for qualified individuals with disabilities and for qualified disabled veterans in job application procedures, as required by applicable law. If you have any difficulty using our online application system and need an accommodation due to a disability, you may contact Talent Acquisition by calling: (415) 483-8800 or by emailing us at For electronic email and mail inquiries, please include a description of your requested accommodation, your name and contact information.See our CCPA Employee and Applicant Privacy Notice.See our Privacy Policy.Note to External Recruiters: All candidate activity and open positions are managed strictly through our Human Resources Department. Our Human Resources Department kindly requests that recruiters not contact employees/hiring managers directly in an attempt to solicit business and present candidates. Please note that failure to comply with this request will be a factor in determining a professional relationship with our organization. Submission of unsolicited resumes prior to an agreement set in place between the Human Resources Department and the recruiting agency will not create any implied obligation. Inquiries on developing a recruiting relationship with us, may be directed to:

Keywords: Ultragenyx Pharmaceutical Inc., Novato , Senior Research Associate I/II, Other , Novato, California

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